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doi: 10.1080/14656566.2018.1448788

In rats and mice, chronic exposure to alcohol causes an increased expression of CYP-2E1 and increases the activity of the enzyme 5- to 7-fold[44, 45]

TMAO producer phenotypes are distinguished by their gut microbiome profiles Because the participants TMAO productivity was partially increased by carnitine supplementation, the gut microbial community may also have been altered